UPPER GI RISK VIDEO

WATCH A VIDEO ON REDUCING RISK OF UPPER GI ULCERS

View a brief educational video on the importance of gastroprotection in certain patients with OA and RA who take NSAIDs. Find out how to identify patients' risk factors and learn about a treatment option.

UPPER GI RISK RESOURCE

READ ABOUT TAKING APPROPRIATE STEPS TO REDUCE PATIENTS'
RISK OF UPPER GI ULCERS

Detailed resource reinforcing the importance of upper GI risk assessment and explaining the importance of gastroprotection while taking high-dose NSAIDs.

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Download the resource to read about Emily's experience taking NSAIDs.

Image of Emily, an OA patient Image of Emily, an OA patient Image of Emily, an OA patient

"I warn people
every single day now
of upper GI ulcer risk factors."

– Emily, OA patient

NSAID UPPER GI RISK DATA

RESULTS FROM SEPARATE STUDIES SHOW THAT UPPER GI ULCERS:

RESULTS FROM SEPARATE STUDIES SHOW THAT UPPER GI ULCERS:

  • ARE COMMON
    Duexis

    Up to 1 in 4

    chronic NSAID users may get an upper GI ulcer1

  • CAN BE ASYMPTOMATIC
    Duexis

    70% of upper GI ulcers

    found in a small endoscopy study were asymptomatic2*

  • MAY OCCUR QUICKLY
    Duexis

    Upper GI ulcers may form within

    6.5 days

    of starting NSAID treatment3

*10 patients were found to have upper GI ulcers and only 3 patients had symptoms at the time of endoscopy. 2

*10 patients were found to have upper GI ulcers and only 3 patients had symptoms at the time of endoscopy. 2

RISK ASSESSMENT TOOL

Know your patients’ risk factors and take appropriate measures to reduce the risk of upper GI toxicity

High-dose NSAIDs alone put your patients at moderate risk for upper GI toxicity. The American College of Gastroenterology calculates upper GI risk by evaluating several common risk factors.1

See your patient’s risk by selecting the risk factors that apply to them.1†

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Low

0 risk factors

High

>2 risk factors or history of a previously complicated ulcer, especially recent

Consider alternative (non-NSAID) therapy.

Upper GI risk:

H. pylori is an independent and additive risk factor and needs to be addressed separately.

INDUSTRY GUIDANCE

Experts agree on the need for gastroprotection with NSAID use in patients at increased risk for NSAID GI toxicity1,4‡

American Academy of Family Physicians logo
American College of Gastroenterology (ACG) logo

icon RA gastroprotectionicon RA gastroprotectionicon RA gastroprotection

Do you have OA or RA patients who could be at risk for NSAID-related upper GI ulcers?

Consider an NSAID + gastroprotection in 1 pill for your OA or RA patients.

See the data

Serious GI events can occur at any time during NSAID use and without warning.5

GI=gastrointestinal; NSAID=nonsteroidal anti-inflammatory drug; OA=osteoarthritis; RA=rheumatoid arthritis.

  • Lanza FL, Chan FK, Quigley EM, Practice Parameters Committee of the American College of Gastroenterology. Guidelines for prevention of NSAID-related ulcer complications. Am J Gastroenterol. 2009;104(3):728-738.
  • Larkai EN, Smith JL, Lidsky MD, Graham DY. Gastroduodenal mucosa and dyspeptic symptoms in arthritic patients during chronic nonsteroidal anti-inflammatory drug use. Am J Gastroenterol. 1987;82(11):1153-1158.
  • Desai JC, Sanyal SM, Goo T, et al. Primary prevention of adverse gastroduodenal effects from short-term use of non-steroidal anti-inflammatory drugs by omeprazole 20 mg in healthy subjects: a randomized, double-blind, placebo-controlled study. Dig Dis Sci. 2008;53(8):2059-2065.
  • Risser A, Donovan D, Heintzman J, Page T. NSAID prescribing precautions. Am Fam Physician. 2009;80(12):1371-1378.
  • DUEXIS (ibuprofen and famotidine) [prescribing information] Horizon.