THE UNMET NEED
To test the hypothesis that the timing of prednisolone administration is important in determining its effect on the diurnal inflammatory process in patients with active RA.
Study compared baseline with values obtained after 5 days of therapy for the 7:30 AM and 2 AM groups, not between dose groups4
This study did not include treatment with RAYOS delayed-release tablets
IR=immediate release
2 AM dosing of prednisolone (active prednisone metabolite) resulted in significant decreases in key inflammatory measures4*†
*The relative efficacy of delayed-release prednisone compared with immediate-release prednisone has not been established.1
†Study compared baseline with values obtained after 5 days of therapy for the 7:30 AM (n=13) and 2 AM (n=13) groups, not between dose groups. P values reflect statistical significance in difference of values between Days 1 and 5 within each dose group.
WHY RAYOS
Tablets shown are not actual size. For illustration purposes only.
‡Individualize dosing based on disease severity and patient response. The timing of administration should take into account the delayed-release pharmacokinetics and the disease or condition being treated.
The release of RAYOS coincides with maximal adrenal cortex activity (2 AM–8 AM), thereby minimizing adrenal suppression1,3,5,6
EFFICACY DATA
CAPRA-2 was a multicenter, double-blind, placebo-controlled, randomized, 12-week study of 350 adult patients with active RA receiving DMARD therapy given either RAYOS or placebo. Primary endpoint was ACR20.
§ACR20 was defined as a 20% improvement in tender or swollen joint count and a 20% improvement in 3 out of 5 of the following: patient’s global assessment, physician’s global assessment, patient’s assessment of pain, degree of disability, and level of acute-phase reactant. ACR50 was defined as a 50% improvement in these criteria.7
From a baseline of ~2 hours, patients taking RAYOS + a DMARD had a median relative reduction of 55% in the duration of morning stiffness vs 33% with placebo + a DMARD (P<0.002).1,2
DOSING INSTRUCTIONS
Multiple dosing strengths enable small titration increments to reach the lowest dose that will maintain an effective clinical response.
When transitioning your patients with RA from immediate-release prednisone1:
Get more information by having your RAYOS representative come to your practice.
Request a representativeFOR YOUR OA KNEE PAIN PATIENTS
Targeted pain relief + reduced systemic exposure of a topical
FIND OUT MORERAYOS is a corticosteroid indicated:
Please see full Prescribing Information.
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit http://www.fda.gov/medwatch, or call 1-800-FDA-1088.
DUEXIS® (ibuprofen and famotidine), a combination of the NSAID ibuprofen and the histamine H2-receptor antagonist famotidine, is indicated for the relief of signs and symptoms of rheumatoid arthritis and osteoarthritis and to decrease the risk of developing upper gastrointestinal ulcers, which in the clinical trials was defined as a gastric and/or duodenal ulcer, in patients who are taking ibuprofen for those indications. The clinical trials primarily enrolled patients less than 65 years of age without a prior history of gastrointestinal ulcer. Controlled trials do not extend beyond 6 months.
For further information on DUEXIS, please see full Prescribing Information, including Boxed Warning and the Medication Guide.
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit http://www.fda.gov/medwatch, or call 1-800-FDA-1088.
PENNSAID® (diclofenac sodium topical solution) 2% w/w (PENNSAID 2%) is a nonsteroidal anti-inflammatory drug indicated for the treatment of the pain of osteoarthritis of the knee(s).
For further information on PENNSAID, please see full Prescribing Information, including Boxed Warning and the Medication Guide.
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit http://www.fda.gov/medwatch, or call 1-800-FDA-1088.
RAYOS is a corticosteroid indicated:
Please see full Prescribing Information.
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit http://www.fda.gov/medwatch, or call 1-800-FDA-1088.
DUEXIS® (ibuprofen and famotidine), a combination of the NSAID ibuprofen and the histamine H2-receptor antagonist famotidine, is indicated for the relief of signs and symptoms of rheumatoid arthritis and osteoarthritis and to decrease the risk of developing upper gastrointestinal ulcers, which in the clinical trials was defined as a gastric and/or duodenal ulcer, in patients who are taking ibuprofen for those indications. The clinical trials primarily enrolled patients less than 65 years of age without a prior history of gastrointestinal ulcer. Controlled trials do not extend beyond 6 months.
For further information on DUEXIS, please see full Prescribing Information, including Boxed Warning and the Medication Guide.
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit http://www.fda.gov/medwatch, or call 1-800-FDA-1088.
PENNSAID® (diclofenac sodium topical solution) 2% w/w (PENNSAID 2%) is a nonsteroidal anti-inflammatory drug indicated for the treatment of the pain of osteoarthritis of the knee(s).
For further information on PENNSAID, please see full Prescribing Information, including Boxed Warning and the Medication Guide.
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit http://www.fda.gov/medwatch, or call 1-800-FDA-1088.